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When autocomplete results are available use up and down arrows to review and enter to select. 0000014217 00000 n
You may need to read it again. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. The vaccine does not contain any preservative and should be administered by a healthcare professional. Contact your doctor or pharmacist if you have any questions about . This explainer is more than 90 days old. Some cases had a fatal outcome. 0000015824 00000 n
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However, a causal relationship with the vaccine has neither been confirmed nor ruled out and more rigorous studies are needed to fully assess the significance of 0000132090 00000 n
A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> on AstraZeneca COVID-19 vaccine for reports of very rare side effects. Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. %PDF-1.3
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Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. 6. 0000007190 00000 n
The vaccine doesn't include any common allergens like egg, latex, milk, gluten, lactose, maize/corn, or peanuts, either. The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. 56 0 obj % AZD1222 FDA Approval Status. 0000006617 00000 n
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Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. 0000004413 00000 n
This article has been translated from its original language. Providing this Surfactants (also called 'emulsifiers') are excipients that can help make sure ingredients like oil and water stay together during the transportation and storage process. Nijmegen, 6545CG The investigation is the latest trouble in Europe for British-Swedish drugmaker AstraZeneca, which has come under pressure to produce more vaccines after it fell tens of millions of doses short. Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. This information was provided by the drug's manufacturer when this drug product was approved for sale in Canada. Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. 0000098136 00000 n
Very low levels of blood platelets (immune thrombocytopenia), that can be associated with bleeding, have been reported very rarely, usually within the first four weeks following vaccination with COVID-19 Vaccine AstraZeneca. Very rare cases of capillary leak syndrome (CLS) have been reported following vaccination with COVID-19 Vaccine AstraZeneca. SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. Read all of this leaflet carefully before the vaccine is given because it contains important information for you. 0000012193 00000 n
assess the risks and benefits taking into consideration their epidemiological situation. %%EOF
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This will help to protect you against COVID-19 in the future. The last nine ingredients on the list are called 'excipients.' Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. endobj 54 0 obj United Kingdom, MedImmune Pharma B.V., Nijmegen The AstraZeneca vaccine is made up of a number of ingredients, including an active ingredient called an 'antigen' and several other non-active ingredients called 'excipients.' (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? It uses a chimpanzee adenovirus to carry spike proteins from the . hb``g``oc`c` @1v=k}u F'SUNZ xc```b``g`a```d@ A+s4@s60J:Up95PA? or call 1-800-FDA-1088 or call AstraZeneca at 1-800-236-9933. If you are allergic to any of the active substances or any of the other ingredients listed in section 6. Oxford-AstraZeneca COVID-19 vaccine efficacy Lancet. 0
Published: 2021-05-07. As new data become available, WHO will update recommendations accordingly. This includes any possible side effects not listed in this leaflet. Do not freeze. 0000100169 00000 n
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xcbd```b``A$c0{.fH "uAY@1bFg210MW stream health workers and immunocompromised persons should be prioritised. Browse our homepage for up to date content or request information about a specific topic from our team of scientists. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. brain, liver, bowel, spleen). 0000102152 00000 n
JZD| COVID-19 Vaccine AstraZeneca stimulates the bodys natural defences (immune system).
The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. 0000001732 00000 n
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stream None of the ingredients in this vaccine can cause COVID-19. 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. 0000003223 00000 n
It is your choice to receive the COVISHIELD . It causes the body to produce its own protection (antibodies) against the virus. Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. 3. /Info 87 0 R It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. 0000002358 00000 n
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,6aYmk}*Oko8/q1(z h^ONc! Solution for injection. You cannot usually choose which vaccine you have. In . Article number: 33474. 0000082759 00000 n
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Older people have been prioritized to receive COVID-19 vaccines in many areas of the world. These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. This means that it is essentially 'sodium-free'.. 18 June 2021. 581 0 obj
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COVID-19 Vaccine (ChAdOx1 S [recombinant]). Use all vaccine in the vial within 6 hours after first puncture. 548 0 obj
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It is a summary of information about the drug and will not tell you everything about the drug. Page last updated Thursday, May 26, 2022 SR-3086-GB-0003 AstraZeneca UK Ltd, Medical Information Department Page 1 of 2 Last Updated January 7, 2021 Return to Index COVID-19 Vaccine AstraZeneca (ChAdOx1 S [recombinant]) - General Ingredients AstraZeneca is providing you with this material as an information service and professional courtesy. News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. 0000006503 00000 n
Other reactions reported in this group include muscle aches (60%), malaise (61%), chills (56%), and feeling feverish (51%). The AstraZeneca vaccine is safe and effective at protecting people from the extremely serious risks of COVID-19, including death, hospitalization and severe disease. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. You will receive 2 injections. 0000053643 00000 n
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Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. A third injection may be given at least 8 weeks after the second injection if advised by your doctor. The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). Function. Here what's in the Pfizer and AstraZeneca jabs (. Oops! Any unused vaccine or waste material should be disposed of in accordance with local requirements. 0000021326 00000 n
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The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. 0000000016 00000 n
How to store COVID-19 Vaccine AstraZeneca 6. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. 0000103016 00000 n
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